The reference site for Trimethoprim

Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections.

WHAT IS Trimethoprim?

Trimethoprim belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. It is an antibiotic used to treat various bacterial infections such as urinary tract infections, traveler’s diarrhea, respiratory and middle ear infections. It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as the common cold or flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

Trimethoprim was formerly marketed by GlaxoWellcome under trade names including Proloprim®Monotrim® and Triprim®. Today, however, these trade names have been licensed to various generic pharmaceutical manufacturers.

In clinical use it is often abbreviated TRI or TMP, and its common laboratory abbreviation is W.

 

Brand Name(s): Monotrim; Proloprim; Trimpex; Triprim
CAS nº: 738-70-5
(trye METH oh prim)

 

Product Info

The sections below will provide you with more specific information and guidelines related to trimethoprim and its correct use. Please read them carefully.

FDA Information

Trimethoprim was first approved in 1973 by the FDA to be administered in combination with sulfamethoxazole (e.g. Bactrim®, Septra®). However, it was approved as a stand-alone drug in 1980.

A prescription is required for this medicine. Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Trimethoprim belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. It is an antibiotic used to treat various bacterial infections such as urinary tract infections, traveler’s diarrhea, respiratory and middle ear infections.

It works by interfering with the production of tetrahydrofolic acid, a chemical that is necessary in order for bacteria and human cells to produce proteins. Trimethoprim inhibits production of tetrahydrofolic acid by inhibiting the enzyme responsible for making tetrahydrofolic acid from dihydrofolic acid. Trimethoprim inhibits the bacterial enzyme more than the corresponding human enzyme. Therefore, trimethoprim has less effect on the production of tetrahydrofolic acid by humans.

This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

Other uses for this medicine

Trimethoprim is also used in combination with sulfamethoxazole, a sulfonamide antibiotic, and known under the name Co-trimoxazole. Owing to its greater efficacy, Co-trimoxazole is indicated for a wider range of infections. For example, it is used as prophylaxis in patients at risk for Pneumocystis jiroveci pneumonia (e.g. AIDS patients and those with some hematological malignancies), as therapy in Whipple’s disease and certain other infections.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Trimethoprim comes as an oral tablet and solution.

The usual dose is 100 mg every 12 hours or 200 mg every 24 hours for 10 days. As with all antibiotics, it is important to complete the entire course of trimethoprim even if your symptoms start to improve before the infection is completely treated.

Persons with kidney diseases may need to receive lower doses. (Diseased kidneys may not eliminate trimethoprim adequately from the body, and levels of trimethoprim may increase in the body and lead to side effects.)

Take this drug exactly as directed by your physician. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Trimethoprim may be taken with or without food, and preferably with a full glass of water.

What special precautions should I follow?

BEFORE TAKING TRIMETHOPRIM:

Tell your doctor if you have kidney disease, or liver disease. You may not be able to take trimethoprim, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Anemia, caused by a reduction in folic acid, can occur in persons receiving trimethoprim in combination with divalproex, valproic acid, methotrexate, pyrimethamine, triamterene, or trimetrexate.

Trimethoprim may increase the effects of phenytoin (Dilantin®) and lead to dangerous side effects. If you are taking phenytoin, notify your doctor of any unusual side effects during treatment with trimethoprim.

The combination of trimethoprim and cyclosporine can increase the risk of kidney damage from cyclosporine.

When trimethoprim and dapsone are used together, increased blood concentrations of both drugs can occur, sometimes with side effects that include a toxic condition called methemoglobinemia.

Rifampin can increase the elimination of trimethoprim by the kidneys and may reduce the effectiveness of trimethoprim.

Trimethoprim is in the FDA pregnancy category C. This means that it is not known whether trimethoprim will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Trimethoprim passes into breast milk and may harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Trimethoprim is not approved for use by children younger than 2 months of age.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose.

Never take a double dose of this medication unless otherwise directed by your doctor.

What side effects can this medication cause?

Stop taking trimethoprim and notify your doctor immediately if you experience any of the following serious side effects:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
unusual bleeding or bruising
sore throat or fever

Other, less serious side effects may be more likely to occur. Continue to take your medication and talk to your doctor if you experience:

nausea, vomiting, or decreased appetite
swollen or sore tongue
a rash or itching

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed, and if necessary talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911.

Symptoms of overdose may include:

nausea
vomiting
dizziness
headache
confusion

Product Images

PICTURES OF TRIMETHOPRIM PILLS

Below you will find images and specific information on the principal types of trimethoprim that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PROLOPRIM®
Strength(s): 100 MG
Imprint: PROLOPRIM 09A
Manufacturer: MONARCH PHARMACEUTICALS

Name: TRIMPEX®
Strength(s): 100 MG
Imprint: ROCHE | TRIMPEX 100
Manufacturer: ROCHE PHARMACEUTICALS

Name: TRIMETHOPRIM
Strength(s): 100 MG
Imprint: 2158 | 93
Manufacturer: TEVA PHARMACEUTICALS

Name: TRIMETHOPRIM
Strength(s): 100 MG
Imprint: DAN DAN | 5571
Manufacturer: WATSON PHARMACEUTICALS (SCHEIN)

Name: TRIMETHOPRIM
Strength(s): 200 MG
Imprint: BL | 35
Manufacturer: TEVA PHARMACEUTICALS

Name: TRIMETHOPRIM
Strength(s): 200 MG
Imprint: APO | TRI 200
Manufacturer: APOTEX INC.

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